A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis
RNF43 is frequently mutated in cancers and negatively regulates Wnt signalling. Here, the authors report that RNF43 phosphorylation at a serine triplet is required for the negative regulation of Wnt signalling and that the phosphorylation of RNF43 suppresses cancer-associated oncogenic RNF43 mutants...
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Nature Publishing Group
2020-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18257-3 |
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doaj-8bbcf86e1ff943ee8f363d3d01a94e7d2021-09-19T11:50:58ZengNature Publishing GroupNature Communications2041-17232020-09-0111111610.1038/s41467-020-18257-3A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesisTadasuke Tsukiyama0Juqi Zou1Jihoon Kim2Shohei Ogamino3Yuki Shino4Takamasa Masuda5Alessandra Merenda6Masaki Matsumoto7Yoichiro Fujioka8Tomonori Hirose9Sayuri Terai10Hidehisa Takahashi11Tohru Ishitani12Keiichi I. Nakayama13Yusuke Ohba14Bon-Kyoung Koo15Shigetsugu Hatakeyama16Department of Biochemistry, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Homeostatic Regulation, Research Institute for Microbial Diseases, Osaka UniversityDepartment of Genetics, University of CambridgeLaboratory of Integrated Signaling Systems, Department of Molecular Medicine, Institute for Molecular and Cellular Regulation, Gunma UniversityFaculty of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-kuDivision of Cell Regulation Systems, Medical Institute of Bioregulation, Kyushu UniversityDepartment of Genetics, University of CambridgeDivision of Proteomics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu UniversityDepartment of Cell Physiology, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Molecular Biology, Yokohama City University Graduate School of Medical ScienceDepartment of Biochemistry, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Biochemistry, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Homeostatic Regulation, Research Institute for Microbial Diseases, Osaka UniversityDivision of Proteomics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu UniversityDepartment of Cell Physiology, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityInstitute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna Biocenter (VBC)Department of Biochemistry, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityRNF43 is frequently mutated in cancers and negatively regulates Wnt signalling. Here, the authors report that RNF43 phosphorylation at a serine triplet is required for the negative regulation of Wnt signalling and that the phosphorylation of RNF43 suppresses cancer-associated oncogenic RNF43 mutants.https://doi.org/10.1038/s41467-020-18257-3 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Tadasuke Tsukiyama Juqi Zou Jihoon Kim Shohei Ogamino Yuki Shino Takamasa Masuda Alessandra Merenda Masaki Matsumoto Yoichiro Fujioka Tomonori Hirose Sayuri Terai Hidehisa Takahashi Tohru Ishitani Keiichi I. Nakayama Yusuke Ohba Bon-Kyoung Koo Shigetsugu Hatakeyama |
| spellingShingle |
Tadasuke Tsukiyama Juqi Zou Jihoon Kim Shohei Ogamino Yuki Shino Takamasa Masuda Alessandra Merenda Masaki Matsumoto Yoichiro Fujioka Tomonori Hirose Sayuri Terai Hidehisa Takahashi Tohru Ishitani Keiichi I. Nakayama Yusuke Ohba Bon-Kyoung Koo Shigetsugu Hatakeyama A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis Nature Communications |
| author_facet |
Tadasuke Tsukiyama Juqi Zou Jihoon Kim Shohei Ogamino Yuki Shino Takamasa Masuda Alessandra Merenda Masaki Matsumoto Yoichiro Fujioka Tomonori Hirose Sayuri Terai Hidehisa Takahashi Tohru Ishitani Keiichi I. Nakayama Yusuke Ohba Bon-Kyoung Koo Shigetsugu Hatakeyama |
| author_sort |
Tadasuke Tsukiyama |
| title |
A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis |
| title_short |
A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis |
| title_full |
A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis |
| title_fullStr |
A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis |
| title_full_unstemmed |
A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis |
| title_sort |
phospho-switch controls rnf43-mediated degradation of wnt receptors to suppress tumorigenesis |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-09-01 |
| description |
RNF43 is frequently mutated in cancers and negatively regulates Wnt signalling. Here, the authors report that RNF43 phosphorylation at a serine triplet is required for the negative regulation of Wnt signalling and that the phosphorylation of RNF43 suppresses cancer-associated oncogenic RNF43 mutants. |
| url |
https://doi.org/10.1038/s41467-020-18257-3 |
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