APOBEC3A deaminates transiently exposed single-strand DNA during LINE-1 retrotransposition

APOBEC3A deaminates transiently exposed single-strand DNA during LINE-1 retrotransposition

Long INterspersed Element-1 (LINE-1 or L1) retrotransposition poses a mutagenic threat to human genomes. Human cells have therefore evolved strategies to regulate L1 retrotransposition. The APOBEC3 (A3) gene family consists of seven enzymes that catalyze deamination of cytidine nucleotides to uridin...

Full description

Bibliographic Details
Main Authors: Sandra R Richardson, Iñigo Narvaiza, Randy A Planegger, Matthew D Weitzman, John V Moran
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-04-01
Series:eLife
Subjects:
LINE-1
APOBEC3A
cytidine deaminase
retrotransposition
Online Access:https://elifesciences.org/articles/02008

Internet

https://elifesciences.org/articles/02008

Similar Items