Association of the CpG methylation pattern of the proximal insulin gene promoter with type 1 diabetes.

Association of the CpG methylation pattern of the proximal insulin gene promoter with type 1 diabetes.

The insulin (INS) region is the second most important locus associated with Type 1 Diabetes (T1D). The study of the DNA methylation pattern of the 7 CpGs proximal to the TSS in the INS gene promoter revealed that T1D patients have a lower level of methylation of CpG -19, -135 and -234 (p = 2.10(-16)...

Full description

Bibliographic Details
Main Authors: Delphine Fradin, Sophie Le Fur, Clémence Mille, Nadia Naoui, Chris Groves, Diana Zelenika, Mark I McCarthy, Mark Lathrop, Pierre Bougnères
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3342174?pdf=render

Internet

http://europepmc.org/articles/PMC3342174?pdf=render

Similar Items