Base editing strategy for insertion of the A673T mutation in the APP gene to prevent the development of AD in vitro

Base editing strategy for insertion of the A673T mutation in the APP gene to prevent the development of AD in vitro

The amyloid precursor protein (APP) is a transmembrane protein mostly found in neurons. Cleavage of this protein by β-secretase can lead to the formation of amyloid-β (Aβ) peptide plaque, which leads to Alzheimer’s disease. Genomic analysis of an Icelandic population that did not show symptoms of Al...

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Bibliographic Details
Main Authors: Antoine Guyon, Joël Rousseau, Francis-Gabriel Bégin, Tom Bertin, Gabriel Lamothe, Jacques P. Tremblay
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
CRISPR/Cas9
Alzheimer's disease
A673T
Islandic mutation
FAD
Base editing
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121000676

Internet

http://www.sciencedirect.com/science/article/pii/S2162253121000676

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