Radiation and Local Anti-CD40 Generate an Effective in situ Vaccine in Preclinical Models of Pancreatic Cancer

Radiation and Local Anti-CD40 Generate an Effective in situ Vaccine in Preclinical Models of Pancreatic Cancer

Radiation therapy induces immunogenic cell death, which can theoretically stimulate T cell priming and induction of tumor-specific memory T cell responses, serving as an in situ vaccine. In practice, this abscopal effect is rarely observed. We use two mouse models of pancreatic cancer to show that a...

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Bibliographic Details
Main Authors: Sayeda Yasmin-Karim, Patrick T. Bruck, Michele Moreau, Sijumon Kunjachan, Gui Zhen Chen, Rajiv Kumar, Stephanie Grabow, Stephanie K. Dougan, Wilfred Ngwa
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
radiotherapy
abscopal effect
immunotherapy
pancreatic cancer
CD40
vitiligo
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02030/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02030/full

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