Exchange catalysis by tapasin exploits conserved and allele-specific features of MHC-I molecules

Exchange catalysis by tapasin exploits conserved and allele-specific features of MHC-I molecules

Tapasin is part of the peptide loading complex necessary for presenting antigenic peptides on MHC-I for the induction of adaptive immunity. Here the authors show that tapasin interacts with MHC-I in both conserved and allele-specific regions to promote antigen presentation, with tapasin L18 and K16...

Full description

Bibliographic Details
Main Authors: Huan Lan, Esam T. Abualrous, Jana Sticht, Laura Maria Arroyo Fernandez, Tamina Werk, Christoph Weise, Martin Ballaschk, Peter Schmieder, Bernhard Loll, Christian Freund
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24401-4

Internet

https://doi.org/10.1038/s41467-021-24401-4

Similar Items