Effect of Anti-IL17 Antibody Treatment Alone and in Combination With Rho-Kinase Inhibitor in a Murine Model of Asthma

Effect of Anti-IL17 Antibody Treatment Alone and in Combination With Rho-Kinase Inhibitor in a Murine Model of Asthma

Background: Interleukin-17 (IL-17) and Rho-kinase (ROCK) play an important role in regulating the expression of inflammatory mediators, immune cell recruitment, hyper-responsiveness, tissue remodeling, and oxidative stress. Modulation of IL-17 and ROCK proteins may represent a promising approach for...

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Bibliographic Details
Main Authors: Tabata M. dos Santos, Renato F. Righetti, Leandro do N. Camargo, Beatriz M. Saraiva-Romanholo, Luciana R. C. R. B. Aristoteles, Flávia C. R. de Souza, Silvia Fukuzaki, Maria I. C. Alonso-Vale, Maysa M. Cruz, Carla M. Prado, Edna A. Leick, Milton A. Martins, Iolanda F. L. C. Tibério
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Physiology
Subjects:
asthma
interleukin-17
Rho-kinase
Y-27632
inflammation
neutralizing antibody
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01183/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.01183/full

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