Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice

Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice

Astrocytes contribute to autism spectrum disorder (ASD) pathophysiology. Here, the authors show that IP3R2 conditional KO mice show ASD-like behaviours and identify astrocyte-derived ATP as a modulator of these behaviours in mice.

Bibliographic Details
Main Authors: Qian Wang, Ying Kong, Ding-Yu Wu, Ji-Hong Liu, Wei Jie, Qiang-Long You, Lang Huang, Jian Hu, Huai-De Chu, Feng Gao, Neng-Yuan Hu, Zhou-Cai Luo, Xiao-Wen Li, Shu-Ji Li, Zhao-Fa Wu, Yu-Long Li, Jian-Ming Yang, Tian-Ming Gao
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23843-0

Internet

https://doi.org/10.1038/s41467-021-23843-0

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