Reversible Valproate-Induced Subacute Encephalopathy Associated With a MT-ATP8 Variant in the Mitochondrial Genome

Reversible Valproate-Induced Subacute Encephalopathy Associated With a MT-ATP8 Variant in the Mitochondrial Genome

Introduction: There are several reported cases of patients developing motor and cognitive neurological impairment under treatment with valproic acid (VPA). We describe a woman who developed a subacute encephalopathy after VPA intake, harboring a mitochondrial DNA variant, previously described as cau...

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Bibliographic Details
Main Authors: Giovanna De Michele, Pierpaolo Sorrentino, Claudia Nesti, Anna Rubegni, Lucia Ruggiero, Silvio Peluso, Antonella Antenora, Mario Quarantelli, Alessandro Filla, Giuseppe De Michele, Filippo M. Santorelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Neurology
Subjects:
valproate
mitochondria
MT-ATP8
metabolic encephalopathy
ammonia
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2018.00728/full

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https://www.frontiersin.org/article/10.3389/fneur.2018.00728/full

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