mTOR Inhibition Induces EGFR Feedback Activation in Association with Its Resistance to Human Pancreatic Cancer

mTOR Inhibition Induces EGFR Feedback Activation in Association with Its Resistance to Human Pancreatic Cancer

The mammalian target of rapamycin (mTOR) is dysregulated in diverse cancers and contributes to tumor progression and drug resistance. The first generation of mTOR inhibitors have failed to show clinical efficiency in treating pancreatic cancers due in part to the feedback relief of the insulin-like...

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Bibliographic Details
Main Authors: Feng Wei, Yandong Zhang, Li Geng, Ping Zhang, Guangyi Wang, Yan Liu
Format: Article
Language:English
Published: MDPI AG 2015-02-01
Series:International Journal of Molecular Sciences
Subjects:
mTORC1/2 kinase
cell resistance
EGFR signaling
FoxO1/3a
feedback activation
pancreatic cancer
Online Access:http://www.mdpi.com/1422-0067/16/2/3267

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http://www.mdpi.com/1422-0067/16/2/3267

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