Development of a polygenic risk score to improve screening for fracture risk: A genetic risk prediction study.

Development of a polygenic risk score to improve screening for fracture risk: A genetic risk prediction study.

<h4>Background</h4>Since screening programs identify only a small proportion of the population as eligible for an intervention, genomic prediction of heritable risk factors could decrease the number needing to be screened by removing individuals at low genetic risk. We therefore tested w...

Full description

Bibliographic Details
Main Authors: Vincenzo Forgetta, Julyan Keller-Baruch, Marie Forest, Audrey Durand, Sahir Bhatnagar, John P Kemp, Maria Nethander, Daniel Evans, John A Morris, Douglas P Kiel, Fernando Rivadeneira, Helena Johansson, Nicholas C Harvey, Dan Mellström, Magnus Karlsson, Cyrus Cooper, David M Evans, Robert Clarke, John A Kanis, Eric Orwoll, Eugene V McCloskey, Claes Ohlsson, Joelle Pineau, William D Leslie, Celia M T Greenwood, J Brent Richards
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-07-01
Series:PLoS Medicine
Online Access:https://doi.org/10.1371/journal.pmed.1003152

Internet

https://doi.org/10.1371/journal.pmed.1003152

Similar Items