Timing Does Matter: Nerve-Mediated HDAC1 Paces the Temporal Expression of Morphogenic Genes During Axolotl Limb Regeneration

Timing Does Matter: Nerve-Mediated HDAC1 Paces the Temporal Expression of Morphogenic Genes During Axolotl Limb Regeneration

Sophisticated axolotl limb regeneration is a highly orchestrated process that requires highly regulated gene expression and epigenetic modification patterns at precise positions and timings. We previously demonstrated two waves of post-amputation expression of a nerve-mediated repressive epigenetic...

Full description

Bibliographic Details
Main Authors: Mu-Hui Wang, Chia-Lang Hsu, Cheng-Han Wu, Ling-Ling Chiou, Yi-Tzang Tsai, Hsuan-Shu Lee, Shau-Ping Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
histone deacetylase
axolotl limb regeneration
blastema
stage-dependent gene modulation
wound epidermis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.641987/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.641987/full

Similar Items