Timing Does Matter: Nerve-Mediated HDAC1 Paces the Temporal Expression of Morphogenic Genes During Axolotl Limb Regeneration

Timing Does Matter: Nerve-Mediated HDAC1 Paces the Temporal Expression of Morphogenic Genes During Axolotl Limb Regeneration

Sophisticated axolotl limb regeneration is a highly orchestrated process that requires highly regulated gene expression and epigenetic modification patterns at precise positions and timings. We previously demonstrated two waves of post-amputation expression of a nerve-mediated repressive epigenetic...

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Bibliographic Details
Main Authors:	Mu-Hui Wang, Chia-Lang Hsu, Cheng-Han Wu, Ling-Ling Chiou, Yi-Tzang Tsai, Hsuan-Shu Lee, Shau-Ping Lin
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-05-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	histone deacetylase axolotl limb regeneration blastema stage-dependent gene modulation wound epidermis
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2021.641987/full

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