Cannabidiol Selectively Binds to the Voltage-Gated Sodium Channel Na<sub>v</sub>1.4 in Its Slow-Inactivated State and Inhibits Sodium Current

Cannabidiol Selectively Binds to the Voltage-Gated Sodium Channel Na<sub>v</sub>1.4 in Its Slow-Inactivated State and Inhibits Sodium Current

Cannabidiol (CBD), one of the cannabinoids from the cannabis plant, can relieve the myotonia resulting from sodium channelopathy, which manifests as repetitive discharges of muscle membrane. We investigated the binding kinetics of CBD to Na<sub>v</sub>1.4 channels on the muscle membrane....

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Bibliographic Details
Main Authors: Chiung-Wei Huang, Pi-Chen Lin, Jian-Lin Chen, Ming-Jen Lee
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Biomedicines
Subjects:
cannabidiol
Na<sub>v</sub>1.4 channel
myotonia
fast inactivation
slow-inactivation
Online Access:https://www.mdpi.com/2227-9059/9/9/1141

Internet

https://www.mdpi.com/2227-9059/9/9/1141

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