Mitotane in the treatment of childhood adrenocortical carcinoma: a potent endocrine disruptor

Adrenocortical carcinoma (ACC) during childhood is a rare malignant tumor that frequently results in glucocorticoid and/or androgen excess. When there are signs of microscopic or macroscopic residual disease, adjuvant therapy is recommended with mitotane, an adrenolytic and cytotoxic drug. In additi...

Full description

Bibliographic Details
Main Authors: Philip D Oddie, Benjamin B Albert, Paul L Hofman, Craig Jefferies, Stephen Laughton, Philippa J Carter
Format: Article
Language:English
Published: Bioscientifica 2018-08-01
Series:Endocrinology, Diabetes & Metabolism Case Reports
Online Access:https://edm.bioscientifica.com/view/journals/edm/2018/1/EDM18-0059.xml