Synthesis of Dextran–Phenoxodiol and Evaluation of Its Physical Stability and Biological Activity

Phenoxodiol, an isoflavene anti-tumor agent, was conjugated on the polysaccharide dextran using immobilized laccase as biocatalyst. The success of the enzymatic conjugation was determined by UV-vis spectrophotometry and its functionalization degree was assessed by 1H NMR and was found to be 3.25 mg...

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Bibliographic Details
Main Authors: Eugene M. H. Yee, Giuseppe Cirillo, Miriam B. Brandl, David StC Black, Orazio Vittorio, Naresh Kumar
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Bioengineering and Biotechnology
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Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2019.00183/full