Mesenchymal Stromal Cells From Emphysematous Donors and Their Extracellular Vesicles Are Unable to Reverse Cardiorespiratory Dysfunction in Experimental Severe Emphysema

Although bone marrow-derived mesenchymal stromal cells (BM-MSCs) from patients with chronic obstructive pulmonary disease (COPD) appear to be phenotypically and functionally similar to BM-MSCs from healthy sources in vitro, the impact of COPD on MSC metabolism and mitochondrial function has not been...

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Bibliographic Details
Main Authors: Mariana A. Antunes, Cassia L. Braga, Tainá B. Oliveira, Jamil Z. Kitoko, Ligia L. Castro, Debora G. Xisto, Mariana S. Coelho, Nazareth Rocha, Rodrigo P. Silva-Aguiar, Celso Caruso-Neves, Eduarda G. Martins, Clara Fernandes Carvalho, Antônio Galina, Daniel J. Weiss, José R. Lapa e Silva, Miquéias Lopes-Pacheco, Fernanda F. Cruz, Patricia R. M. Rocco
Format: Article
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
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