Mesenchymal Stromal Cells From Emphysematous Donors and Their Extracellular Vesicles Are Unable to Reverse Cardiorespiratory Dysfunction in Experimental Severe Emphysema

Mesenchymal Stromal Cells From Emphysematous Donors and Their Extracellular Vesicles Are Unable to Reverse Cardiorespiratory Dysfunction in Experimental Severe Emphysema

Although bone marrow-derived mesenchymal stromal cells (BM-MSCs) from patients with chronic obstructive pulmonary disease (COPD) appear to be phenotypically and functionally similar to BM-MSCs from healthy sources in vitro, the impact of COPD on MSC metabolism and mitochondrial function has not been...

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Bibliographic Details
Main Authors: Mariana A. Antunes, Cassia L. Braga, Tainá B. Oliveira, Jamil Z. Kitoko, Ligia L. Castro, Debora G. Xisto, Mariana S. Coelho, Nazareth Rocha, Rodrigo P. Silva-Aguiar, Celso Caruso-Neves, Eduarda G. Martins, Clara Fernandes Carvalho, Antônio Galina, Daniel J. Weiss, José R. Lapa e Silva, Miquéias Lopes-Pacheco, Fernanda F. Cruz, Patricia R. M. Rocco
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cell therapy
COPD
mesenchymal stromal cells
extracellular vesicles
inflammation
macrophages
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.661385/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.661385/full

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