Gemin4 is an essential gene in mice, and its overexpression in human cells causes relocalization of the SMN complex to the nucleoplasm

Gemin4 is an essential gene in mice, and its overexpression in human cells causes relocalization of the SMN complex to the nucleoplasm

Gemin4 is a member of the Survival Motor Neuron (SMN) protein complex, which is responsible for the assembly and maturation of Sm-class small nuclear ribonucleoproteins (snRNPs). In metazoa, Sm snRNPs are assembled in the cytoplasm and subsequently imported into the nucleus. We previously showed tha...

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Bibliographic Details
Main Authors: Ingo D. Meier, Michael P. Walker, A. Gregory Matera
Format: Article
Language:English
Published: The Company of Biologists 2018-02-01
Series:Biology Open
Subjects:
Survival motor neuron
Spinal muscular atrophy
Nuclear import
Ribonucleoproteins
Spliceosome snRNPs
Cajal bodies
Online Access:http://bio.biologists.org/content/7/2/bio032409

Internet

http://bio.biologists.org/content/7/2/bio032409

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