Selective β2-Adrenoceptor Blockade Rescues Mandibular Growth Retardation in Adolescent Rats Exposed to Chronic Intermittent Hypoxia

Selective β2-Adrenoceptor Blockade Rescues Mandibular Growth Retardation in Adolescent Rats Exposed to Chronic Intermittent Hypoxia

Activation of the sympathoadrenal system is associated with sleep apnea-related symptoms and metabolic dysfunction induced by chronic intermittent hypoxia (IH). IH can induce hormonal imbalances and growth retardation of the craniofacial bones. However, the relationship between IH and β2-adrenergic...

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Bibliographic Details
Main Authors: Haixin Hong, Jun Hosomichi, Hideyuki Maeda, Yuji Ishida, Risa Usumi-Fujita, Ken-ichi Yoshida, Takashi Ono
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Physiology
Subjects:
obstructive sleep apnea
intermittent hypoxia
β2-adrenergic receptor
leptin
serotonin
skeletal growth
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.676270/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.676270/full

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