Alcohol use disorder causes global changes in splicing in the human brain

Abstract Alcohol use disorder (AUD) is a widespread disease leading to the deterioration of cognitive and other functions. Mechanisms by which alcohol affects the brain are not fully elucidated. Splicing constitutes a nuclear process of RNA maturation, which results in the formation of the transcrip...

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Bibliographic Details
Main Authors: Derek Van Booven, Mengying Li, J. Sunil Rao, Ilya O. Blokhin, R. Dayne Mayfield, Estelle Barbier, Markus Heilig, Claes Wahlestedt
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-020-01163-z