The phosphatase Shp1 interacts with and dephosphorylates cortactin to inhibit invadopodia function

The phosphatase Shp1 interacts with and dephosphorylates cortactin to inhibit invadopodia function

Abstract Background Invadopodia are actin-based cell-membrane protrusions associated with the extracellular matrix degradation accompanying cancer invasion. The elucidation of the molecular mechanisms leading to invadopodia formation and activity is central for the prevention of tumor spreading and...

Full description

Bibliographic Details
Main Authors: Alessia Varone, Chiara Amoruso, Marcello Monti, Manpreet Patheja, Adelaide Greco, Luigi Auletta, Antonella Zannetti, Daniela Corda
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Cell Communication and Signaling
Subjects:
Src homology region 2 domain-containing phosphatase-1 (Shp1)
Cortactin
Invadopodia
Glycerophosphoinositols
Phosphoinositides
Cancer
Online Access:https://doi.org/10.1186/s12964-021-00747-6

Internet

https://doi.org/10.1186/s12964-021-00747-6

Similar Items