Simvastatin and ROCK Inhibitor Y-27632 Inhibit Myofibroblast Differentiation of Graves’ Ophthalmopathy-Derived Orbital Fibroblasts via RhoA-Mediated ERK and p38 Signaling Pathways

Simvastatin and ROCK Inhibitor Y-27632 Inhibit Myofibroblast Differentiation of Graves’ Ophthalmopathy-Derived Orbital Fibroblasts via RhoA-Mediated ERK and p38 Signaling Pathways

Transforming growth factor-β (TGF-β)-induced differentiation of orbital fibroblasts into myofibroblasts is an important pathogenesis of Graves’ ophthalmopathy (GO) and leads to orbital tissue fibrosis. In the present study, we explored the antifibrotic effects of simvastatin and ROCK inhibitor Y-276...

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Bibliographic Details
Main Authors: Yi-Hsuan Wei, Shu-Lang Liao, Sen-Hsu Wang, Chia-Chun Wang, Chang-Hao Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Endocrinology
Subjects:
simvastatin
Y-27632
Ras homolog family member A (RhoA)
Rho‑associated protein kinase (ROCK)
myofibroblast
Graves’ ophthalmopathy
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2020.607968/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2020.607968/full

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