Structural model, functional modulation by ivermectin and tissue localization of Haemonchus contortus P-glycoprotein-13

Haemonchus contortus, one of the most economically important parasites of small ruminants, has become resistant to the anthelmintic ivermectin. Deciphering the role of P-glycoproteins in ivermectin resistance is desirable for understanding and overcoming this resistance. In the model nematode, Caeno...

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Bibliographic Details
Main Authors: Marion David, Chantal Lebrun, Thomas Duguet, Franck Talmont, Robin Beech, Stéphane Orlowski, François André, Roger K. Prichard, Anne Lespine
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320717301306