Convergent Loss of the Necroptosis Pathway in Disparate Mammalian Lineages Shapes Viruses Countermeasures

Convergent Loss of the Necroptosis Pathway in Disparate Mammalian Lineages Shapes Viruses Countermeasures

Programmed cell death is a vital process in the life cycle of organisms. Necroptosis, an evolutionary form of programmed necrosis, contributes to the innate immune response by killing pathogen-infected cells. This virus-host interaction pathway is organized around two components: the receptor-intera...

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Bibliographic Details
Main Authors: Ana Águeda-Pinto, Luís Q. Alves, Fabiana Neves, Grant McFadden, Bertram L. Jacobs, L. Filipe C. Castro, Masmudur M. Rahman, Pedro J. Esteves
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
necroptosis
mammalian lineages
RIPK3
MLKL
convergent gene loss
host-range interactions
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.747737/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.747737/full

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