Hydrostatic Pressure Influences HIF-2 Alpha Expression in Chondrocytes

Hydrostatic Pressure Influences HIF-2 Alpha Expression in Chondrocytes

Hypoxia-inducible factor (HIF)-2α is considered to play a major role in the progression of osteoarthritis. Recently, it was reported that pressure amplitude influences HIF-2α expression in murine endothelial cells. We examined whether hydrostatic pressure is involved in expression of HIF-2α in artic...

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Bibliographic Details
Main Authors: Hiroaki Inoue, Yuji Arai, Tsunao Kishida, Ryu Terauchi, Kuniaki Honjo, Shuji Nakagawa, Shinji Tsuchida, Tomohiro Matsuki, Keiichirou Ueshima, Hiroyoshi Fujiwara, Osam Mazda, Toshikazu Kubo
Format: Article
Language:English
Published: MDPI AG 2015-01-01
Series:International Journal of Molecular Sciences
Subjects:
hypoxia inducible factor (HIF)-2α
hydrostatic pressure
chondrocytes
hypertrophic differentiation
osteoarthritis
cartilage degeneration
inflammation
Online Access:http://www.mdpi.com/1422-0067/16/1/1043

Internet

http://www.mdpi.com/1422-0067/16/1/1043

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