RNA-Seq reveals the existence of a CDKN1C-E2F1-TP53 axis that is altered in human T-cell lymphoblastic lymphomas

RNA-Seq reveals the existence of a CDKN1C-E2F1-TP53 axis that is altered in human T-cell lymphoblastic lymphomas

Abstract Background Precursor T-cell lymphoblastic lymphomas (T-LBL) are rare aggressive hematological malignancies that mainly develop in children. As in other cancers, the loss of cell cycle control plays a prominent role in the pathogenesis in these malignancies that is primarily attributed to lo...

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Bibliographic Details
Main Authors: Pilar López-Nieva, Pablo Fernández-Navarro, Concepción Vaquero-Lorenzo, María Villa-Morales, Osvaldo Graña-Castro, María Ángeles Cobos-Fernández, José Luis López-Lorenzo, Pilar Llamas, Laura González-Sanchez, Isabel Sastre, Marina Pollan, Marcos Malumbres, Javier Santos, José Fernández-Piqueras
Format: Article
Language:English
Published: BMC 2018-04-01
Series:BMC Cancer
Subjects:
T-cell lymphoblastic lymphoma
CDKN1C-E2F1-TP53 deregulation
Promoter hypermethylation
Deregulation of miRNAs
Online Access:http://link.springer.com/article/10.1186/s12885-018-4304-y

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http://link.springer.com/article/10.1186/s12885-018-4304-y

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