Histological, immunohistochemical and mRNA gene expression responses in coeliac disease patients challenged with gluten using PAXgene fixed paraffin-embedded duodenal biopsies

Histological, immunohistochemical and mRNA gene expression responses in coeliac disease patients challenged with gluten using PAXgene fixed paraffin-embedded duodenal biopsies

Abstract Background There is an unmet need for novel treatments, such as drugs or vaccines, adjunctive to or replacing a burdensome life-long gluten-free diet for coeliac disease. The gold standard for successful treatment is a healed small intestinal mucosa, and therefore, the outcome measures in p...

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Bibliographic Details
Main Authors: Juha Taavela, Keijo Viiri, Alina Popp, Mikko Oittinen, Valeriia Dotsenko, Markku Peräaho, Synnöve Staff, Jani Sarin, Francisco Leon, Markku Mäki, Jorma Isola
Format: Article
Language:English
Published: BMC 2019-11-01
Series:BMC Gastroenterology
Subjects:
Coeliac disease
Biopsy
Morphometry
Immunohistochemistry
mRNA
PAXgene
Online Access:http://link.springer.com/article/10.1186/s12876-019-1089-7

Internet

http://link.springer.com/article/10.1186/s12876-019-1089-7

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