Human peripheral CD4+ Vdelta1+ gamma delta T cells can develop into alpha beta T cells

Human peripheral CD4+ Vdelta1+ gamma delta T cells can develop into alpha beta T cells

The lifelong generation of alpha beta T cells enables us to continuously build immunity against pathogens and malignancies despite the loss of thymic function with age. Consequently, alpha beta T-cell development has to occur independently of the thymus. However, the sites and mechanisms of extrathy...

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Bibliographic Details
Main Authors: Hendrik eZiegler, Christian eWelker, Marco eSterk, Jan eHaarer, Hans-Georg eRammensee, Rupert eHandgretinger, Karin eSchilbach
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-12-01
Series:Frontiers in Immunology
Subjects:
Inflammation
Gamma Delta T cells
extrathymic T cell development
Vdelta1 gamma delta T cells
extrathymic T cell progenitor
Hematopoietic Progenitor Cell
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00645/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00645/full

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