WASp Is Crucial for the Unique Architecture of the Immunological Synapse in Germinal Center B-Cells

WASp Is Crucial for the Unique Architecture of the Immunological Synapse in Germinal Center B-Cells

B-cells undergo somatic hypermutation and affinity maturation in germinal centers. Somatic hypermutated germinal center B-cells (GCBs) compete to engage with and capture antigens on follicular dendritic cells. Recent studies show that when encountering membrane antigens, GCBs generate actin-rich pod...

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Bibliographic Details
Main Authors: Yanan Li, Anshuman Bhanja, Arpita Upadhyaya, Xiaodong Zhao, Wenxia Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
B-lymphocytes
germinal center
actin
WASp
signal transduction
immunological synapse
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.646077/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.646077/full

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