Residual Disease in a Novel Xenograft Model of RUNX1-Mutated, Cytogenetically Normal Acute Myeloid Leukemia.

Residual Disease in a Novel Xenograft Model of RUNX1-Mutated, Cytogenetically Normal Acute Myeloid Leukemia.

Cytogenetically normal acute myeloid leukemia (CN-AML) patients harboring RUNX1 mutations have a dismal prognosis with anthracycline/cytarabine-based chemotherapy. We aimed to develop an in vivo model of RUNX1-mutated, CN-AML in which the nature of residual disease in this molecular disease subset c...

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Bibliographic Details
Main Authors: Umayal Sivagnanalingam, Marlene Balys, Allison Eberhardt, Nancy Wang, Jason R Myers, John M Ashton, Michael W Becker, Laura M Calvi, Jason H Mendler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4503761?pdf=render

Internet

http://europepmc.org/articles/PMC4503761?pdf=render

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