Peroxiredoxin II negatively regulates BMP2-induced osteoblast differentiation and bone formation via PP2A Cα-mediated Smad1/5/9 dephosphorylation

Bone health: Enzyme protects against damage during stress An antioxidant enzyme actively works to reduce bone synthesis under oxidative stress conditions in order to protect bone cells from damage and cell death. Bone is generated by cells called osteoblasts, which differentiate from stem cells. In...

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Bibliographic Details
Main Authors: Kyeong-Min Kim, Do-Young Kim, Dong-Seok Lee, Jung-Woo Kim, Jeong-Tae Koh, Eun-Jung Kim, Won-Gu Jang
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-019-0263-x