Novel Redox-Dependent Esterase Activity (EC 3.1.1.2) for DJ-1: Implications for Parkinson’s Disease

Novel Redox-Dependent Esterase Activity (EC 3.1.1.2) for DJ-1: Implications for Parkinson’s Disease

Mutations the in human DJ-1 (hDJ-1) gene are associated with early-onset autosomal recessive forms of Parkinson’s disease (PD). hDJ-1/parkinsonism associated deglycase (PARK7) is a cytoprotective multi-functional protein that contains a conserved cysteine-protease domain. Given that cysteine-proteas...

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Bibliographic Details
Main Authors: Emmanuel Vázquez-Mayorga, Ángel G. Díaz-Sánchez, Ruben K. Dagda, Carlos A. Domínguez-Solís, Raul Y. Dagda, Cynthia K. Coronado-Ramírez, Alejandro Martínez-Martínez
Format: Article
Language:English
Published: MDPI AG 2016-08-01
Series:International Journal of Molecular Sciences
Subjects:
4-nitrophenyl acetate
human carboxyl esterase
redox sensor
oxidative stress
DJ1/PARK7
ROS
Parkinson’s disease
Online Access:http://www.mdpi.com/1422-0067/17/8/1346

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http://www.mdpi.com/1422-0067/17/8/1346

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