O6-methylguanine-DNA methyltransferase (MGMT) Promoter methylation is a rare event in soft tissue sarcoma

O6-methylguanine-DNA methyltransferase (MGMT) Promoter methylation is a rare event in soft tissue sarcoma

<p>Abstract</p> <p>Background</p> <p>Gene silencing of O6-methylguanine–DNA methyltransferase (MGMT) by promoter methylation improves the outcome of glioblastoma patients after combined therapy of alkylating chemotherapeutic agents and radiation. The purpose of this stu...

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Bibliographic Details
Main Authors: Jakob Jens, Hille Maren, Sauer Christian, Ströbel Philipp, Wenz Frederik, Hohenberger Peter
Format: Article
Language:English
Published: BMC 2012-10-01
Series:Radiation Oncology
Subjects:
Soft tissue sarcoma
O6-methylguanine–DNA methyltransferase
Promoter methylation
Temozolomide
Epigenetic gene silencing
Radiation therapy
Online Access:http://www.ro-journal.com/content/7/1/180

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http://www.ro-journal.com/content/7/1/180

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