Small molecule disruption of G protein βγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats.

The purpose of this study was to determine whether blocking of G protein βγ (Gβγ) signaling halts heart failure (HF) progression by macrophage phenotype manipulation. Cardiac Gβγ signaling plays a crucial role in HF pathogenesis. Previous data suggested that inhibiting Gβγ signaling reprograms T hel...

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Bibliographic Details
Main Authors:	Vengadeshprabhu Karuppagounder, Anamika Bajpai, Shu Meng, Somasundaram Arumugam, Remya Sreedhar, Vijayasree V Giridharan, Ashrith Guha, Arvind Bhimaraj, Keith A Youker, Suresh S Palaniyandi, Harry Karmouty-Quintana, Fadia Kamal, Kara L Spiller, Kenichi Watanabe, Rajarajan A Thandavarayan
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2018-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC6053176?pdf=render

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http://europepmc.org/articles/PMC6053176?pdf=render

Small molecule disruption of G protein βγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats.

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