Rottlerin, a natural polyphenol compound, inhibits upregulation of matrix metalloproteinase-9 and brain astrocytic migration by reducing PKC-δ-dependent ROS signal

Rottlerin, a natural polyphenol compound, inhibits upregulation of matrix metalloproteinase-9 and brain astrocytic migration by reducing PKC-δ-dependent ROS signal

Abstract Background Upregulation of matrix metalloproteinase-9 (MMP-9) has been indicated as one of the inflammatory biomarkers. In the central nervous system (CNS), the MMP-9 is induced by several proinflammatory mediators and participates in the CNS disorders, including inflammation and neurodegen...

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Bibliographic Details
Main Authors: Tsong-Hai Lee, Jiun-Liang Chen, Pei-Shan Liu, Ming-Ming Tsai, Su-Jane Wang, Hsi-Lung Hsieh
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Neuroinflammation
Subjects:
Rottlerin
Matrix metalloproteinase-9
Protein kinase C-δ
Reactive oxygen species
Brain astrocytes
Neuroinflammation
Online Access:http://link.springer.com/article/10.1186/s12974-020-01859-5

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http://link.springer.com/article/10.1186/s12974-020-01859-5

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