Immune checkpoint modulation: Tenets and implications in glioblastoma

Immune checkpoint modulation: Tenets and implications in glioblastoma

Glioblastoma (GBM) is the most common primary central nervous system tumor, and despite advances made in traditional chemotherapy and radiation, it continues to carry a poor prognosis. The discovery of the profound immunosuppressive microenvironment created by GBM has given insight on the aggressive...

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Bibliographic Details
Main Authors: John P Lynes, Victoria E Sanchez, Anthony K Nwankwo, Gifty A Dominah, Edjah K Nduom
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Glioma
Subjects:
4-1BB
blockade
checkpoint
cytotoxic T-lymphocyte-associated protein 4
glioblastoma
glucocorticoid-induced tumor necrosis factor receptor
immunotherapy
inhibitor
lymphocyte-activating gene-3
OX-40
programmed cell death-1
T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain
T-cell immunoglobulin and mucin domain 3
Online Access:http://www.jglioma.com/article.asp?issn=2589-6113;year=2019;volume=2;issue=1;spage=20;epage=29;aulast=Lynes

Internet

http://www.jglioma.com/article.asp?issn=2589-6113;year=2019;volume=2;issue=1;spage=20;epage=29;aulast=Lynes

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