Protective Allele for Multiple Sclerosis HLA-DRB1*01:01 Provides Kinetic Discrimination of Myelin and Exogenous Antigenic Peptides

Protective Allele for Multiple Sclerosis HLA-DRB1*01:01 Provides Kinetic Discrimination of Myelin and Exogenous Antigenic Peptides

Risk of the development of multiple sclerosis (MS) is known to be increased in individuals bearing distinct class II human leukocyte antigen (HLA) variants, whereas some of them may have a protective effect. Here we analyzed distribution of a highly polymorphous HLA-DRB1 locus in more than one thous...

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Bibliographic Details
Main Authors: Azad Mamedov, Nadezhda Vorobyeva, Ioanna Filimonova, Maria Zakharova, Ivan Kiselev, Vitalina Bashinskaya, Natalia Baulina, Alexey Boyko, Alexander Favorov, Olga Kulakova, Rustam Ziganshin, Ivan Smirnov, Alina Poroshina, Igor Shilovskiy, Musa Khaitov, Yuri Sykulev, Olga Favorova, Valentin Vlassov, Alexander Gabibov, Alexey Belogurov
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
myelin basic protein
multiple sclerosis
human leukocyte antigen
protective allele
epitope library
hemagglutinin
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03088/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.03088/full

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