Proteasome inhibitor (MG132) rescues Nav1.5 protein content and the cardiac sodium current in dystrophin-deficient mdx5cv mice

Proteasome inhibitor (MG132) rescues Nav1.5 protein content and the cardiac sodium current in dystrophin-deficient mdx5cv mice

The cardiac voltage-gated sodium channel, Nav1.5, plays a central role in cardiac excitability and impulse propagation and associates with the dystrophin multiprotein complex (DMC) at the lateral membrane of cardiomyocytes. It was previously shown that Nav1.5 protein content and the sodium current (...

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Bibliographic Details
Main Authors: Jean-Sebastien eRougier, Bruno eGavillet, Hugues eAbriel
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-03-01
Series:Frontiers in Physiology
Subjects:
Dystrophin
Electrophysiology
Sodium Channels
inhibitors
Proteasome
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00051/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00051/full

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