Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis

Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis

Calcium (Ca2+)-evoked release of neurotransmitters from synaptic vesicles requires mechanisms both to prevent un-initiated fusion of vesicles (clamping) and to trigger fusion following Ca2+-influx. The principal components involved in these processes are the vesicular fusion machinery (SNARE protein...

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Bibliographic Details
Main Authors: Sathish Ramakrishnan, Manindra Bera, Jeff Coleman, James E Rothman, Shyam S Krishnakumar
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-05-01
Series:eLife
Subjects:
neurotransmission
vesicle fusion
synaptotagmin
complexin
calcium
Online Access:https://elifesciences.org/articles/54506

Internet

https://elifesciences.org/articles/54506

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