APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression

APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression

Alzheimer´s disease (AD) is characterized by an accumulation of Amyloid-β (Aβ), released by sequential proteolytic processing of the amyloid precursor protein (APP) by β- and γ-secretase. Aβ peptides can aggregate, leading to toxic Aβ oligomers and amyloid plaque formation. Aβ accumulation is not on...

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Bibliographic Details
Main Authors: Marcus Otto Grimm, Janine eMett, Christoph Peter Stahlmann, Sven eGrösgen, Viola Jessica Haupenthal, Tamara eBlümel, Benjamin eHundsdörfer, Valerie Christin Zimmer, Nadine Tamara Mylonas, Heikki eTanila, Ulrike eMüller, Heike Sabine Grimm, Tobias eHartmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
Neprilysin
gene regulation
Alzheimer´s disease
AICD
APP intracellular domain
Aβ degradation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00077/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00077/full

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