Co-culturing nucleus pulposus mesenchymal stem cells with notochordal cell-rich nucleus pulposus explants attenuates tumor necrosis factor-α-induced senescence

Co-culturing nucleus pulposus mesenchymal stem cells with notochordal cell-rich nucleus pulposus explants attenuates tumor necrosis factor-α-induced senescence

Abstract Background Cell therapy for the treatment of intervertebral disc degeneration (IDD) faces serious barriers since tissue-specific adult cells such as nucleus pulposus cells (NPCs) have limited proliferative ability and poor regenerative potential; in addition, it is difficult for exogenous a...

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Bibliographic Details
Main Authors: Xiao-Chuan Li, Mao-Sheng Wang, Wei Liu, Cheng-Fan Zhong, Gui-Bin Deng, Shao-Jian Luo, Chun-Ming Huang
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Stem Cell Research & Therapy
Subjects:
Intervertebral disc degeneration
Notochordal cell-rich nucleus pulposus explants
Nucleus pulposus mesenchymal stem cells
Senescence
TNF-α
Online Access:http://link.springer.com/article/10.1186/s13287-018-0919-9

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http://link.springer.com/article/10.1186/s13287-018-0919-9

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