The RNA‐helicase DDX21 upregulates CEP55 expression and promotes neuroblastoma

The RNA‐helicase DDX21 upregulates CEP55 expression and promotes neuroblastoma

Approximately 25% of human neuroblastoma is caused by amplification of the MYCN oncogene, which leads to overexpression of N‐Myc oncoprotein. The survival rate for this patient subtype is <50%. Here, we show that N‐Myc protein bound to the DEAD‐box RNA helicase DDX21 gene promoter and upregulated...

Full description

Bibliographic Details
Main Authors: Vina Putra, Amy J. Hulme, Andrew E. Tee, Jane Q.J. Sun, Bernard Atmadibrata, Nicholas Ho, Jingwei Chen, Jixuan Gao, Murray D. Norris, Michelle Haber, Maria Kavallaris, Michelle J. Henderson, Joshua McCarroll, Toby Trahair, Tao Liu, Pei Y. Liu
Format: Article
Language:English
Published: Wiley 2021-04-01
Series:Molecular Oncology
Subjects:
amplification
CEP55
DDX21
MYCN
neuroblastoma
N‐Myc
Online Access:https://doi.org/10.1002/1878-0261.12906

Internet

https://doi.org/10.1002/1878-0261.12906

Similar Items