Frequent exchange of the DNA polymerase during bacterial chromosome replication

Frequent exchange of the DNA polymerase during bacterial chromosome replication

The replisome is a multiprotein machine that carries out DNA replication. In Escherichia coli, a single pair of replisomes is responsible for duplicating the entire 4.6 Mbp circular chromosome. In vitro studies of reconstituted E. coli replisomes have attributed this remarkable processivity to the h...

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Bibliographic Details
Main Authors: Thomas R Beattie, Nitin Kapadia, Emilien Nicolas, Stephan Uphoff, Adam JM Wollman, Mark C Leake, Rodrigo Reyes-Lamothe
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-03-01
Series:eLife
Subjects:
DNA replication
replisome
bacteria
single-molecule microscopy
genome integrity
Online Access:https://elifesciences.org/articles/21763

Internet

https://elifesciences.org/articles/21763

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