GSK-3Beta-Dependent Activation of GEF-H1/ROCK Signaling Promotes LPS-Induced Lung Vascular Endothelial Barrier Dysfunction and Acute Lung Injury

GSK-3Beta-Dependent Activation of GEF-H1/ROCK Signaling Promotes LPS-Induced Lung Vascular Endothelial Barrier Dysfunction and Acute Lung Injury

The bacterial endotoxin or lipopolysaccharide (LPS) leads to the extensive vascular endothelial cells (EC) injury under septic conditions. Guanine nucleotide exchange factor-H1 (GEF-H1)/ROCK signaling not only involved in LPS-induced overexpression of pro-inflammatory mediator in ECs but also implic...

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Bibliographic Details
Main Authors: Lei Yi, Xiaoqin Huang, Feng Guo, Zengding Zhou, Mengling Chang, Jingning Huan
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
lipopolysaccharide
endothelial cell
ALI
GSK-3beta
GEF-H1
ROCK
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00357/full

Internet

http://journal.frontiersin.org/article/10.3389/fcimb.2017.00357/full

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