Deregulated miRNAs Contribute to Silencing of B-Cell Specific Transcription Factors and Activation of NF-κB in Classical Hodgkin Lymphoma

Deregulated miRNAs Contribute to Silencing of B-Cell Specific Transcription Factors and Activation of NF-κB in Classical Hodgkin Lymphoma

A hallmark of classical Hodgkin lymphoma (cHL) is the attenuation of B-cell transcription factors leading to global transcriptional reprogramming. The role of miRNAs (microRNAs) involved in this process is poorly studied. Therefore, we performed global miRNA expression profiling using RNA-seq on com...

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Bibliographic Details
Main Authors: Julia Paczkowska, Joanna Janiszewska, Adam Ustaszewski, Julia Bein, Marcin Skalski, Agnieszka Dzikiewicz-Krawczyk, Natalia Rozwadowska, Martin-Leo Hansmann, Sylvia Hartmann, Maciej Giefing
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
classical Hodgkin lymphoma
microdissection
miRNA
loss of B-cell phenotype
NF-κB
B-cell transcription factors
Online Access:https://www.mdpi.com/2072-6694/13/13/3131

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https://www.mdpi.com/2072-6694/13/13/3131

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