Comparative immunogenicity and protective capacity of two Dengue-4 vaccine candidates based on P64k-envelope domain III

Comparative immunogenicity and protective capacity of two Dengue-4 vaccine candidates based on P64k-envelope domain III

In this work we compared, in the same immunization schedule in mice, two vaccine candidates against Dengue-4 based on the envelope protein domain III and the carrier P64k. Their molecular and antigenic features, immunogenicity and protective capacity in the viral encephalitis murine model are assess...

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Bibliographic Details
Main Authors: Laura Lazo, Lázaro Gil, Aída Zulueta, Iris Valdés, Yordanka Soria, Yaremis Romero, Gerardo Guillén, Lisset Hermida
Format: Article
Language:English
Published: Elfos Scientiae
Series:Biotecnología Aplicada
Subjects:
dengue
vaccine
p64k
carrier
Online Access:http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1027-28522009000400006&lng=en&tlng=en
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spelling doaj-8c50141db2604d7abf25bb3b2d6dcaab2020-11-25T03:59:13ZengElfos ScientiaeBiotecnología Aplicada1027-2852264333337S1027-28522009000400006Comparative immunogenicity and protective capacity of two Dengue-4 vaccine candidates based on P64k-envelope domain IIILaura Lazo0Lázaro Gil1Aída Zulueta2Iris Valdés3Yordanka Soria4Yaremis Romero5Gerardo Guillén6Lisset Hermida7Center for Genetic Engineering and BiotechnologyCenter for Genetic Engineering and BiotechnologyCenter for Genetic Engineering and BiotechnologyCenter for Genetic Engineering and BiotechnologyCenter for Genetic Engineering and BiotechnologyCenter for Genetic Engineering and BiotechnologyCenter for Genetic Engineering and BiotechnologyCenter for Genetic Engineering and BiotechnologyIn this work we compared, in the same immunization schedule in mice, two vaccine candidates against Dengue-4 based on the envelope protein domain III and the carrier P64k. Their molecular and antigenic features, immunogenicity and protective capacity in the viral encephalitis murine model are assessed. Our study endorses the strategy of using both sites of inclusion within the same P64k molecule, in order to enhance the immunogenicity of protein fragments.http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1027-28522009000400006&lng=en&tlng=endenguevaccinep64kcarrier
collection DOAJ
language English
format Article
sources DOAJ
author Laura Lazo
Lázaro Gil
Aída Zulueta
Iris Valdés
Yordanka Soria
Yaremis Romero
Gerardo Guillén
Lisset Hermida
spellingShingle Laura Lazo
Lázaro Gil
Aída Zulueta
Iris Valdés
Yordanka Soria
Yaremis Romero
Gerardo Guillén
Lisset Hermida
Comparative immunogenicity and protective capacity of two Dengue-4 vaccine candidates based on P64k-envelope domain III
Biotecnología Aplicada
dengue
vaccine
p64k
carrier
author_facet Laura Lazo
Lázaro Gil
Aída Zulueta
Iris Valdés
Yordanka Soria
Yaremis Romero
Gerardo Guillén
Lisset Hermida
author_sort Laura Lazo
title Comparative immunogenicity and protective capacity of two Dengue-4 vaccine candidates based on P64k-envelope domain III
title_short Comparative immunogenicity and protective capacity of two Dengue-4 vaccine candidates based on P64k-envelope domain III
title_full Comparative immunogenicity and protective capacity of two Dengue-4 vaccine candidates based on P64k-envelope domain III
title_fullStr Comparative immunogenicity and protective capacity of two Dengue-4 vaccine candidates based on P64k-envelope domain III
title_full_unstemmed Comparative immunogenicity and protective capacity of two Dengue-4 vaccine candidates based on P64k-envelope domain III
title_sort comparative immunogenicity and protective capacity of two dengue-4 vaccine candidates based on p64k-envelope domain iii
publisher Elfos Scientiae
series Biotecnología Aplicada
issn 1027-2852
description In this work we compared, in the same immunization schedule in mice, two vaccine candidates against Dengue-4 based on the envelope protein domain III and the carrier P64k. Their molecular and antigenic features, immunogenicity and protective capacity in the viral encephalitis murine model are assessed. Our study endorses the strategy of using both sites of inclusion within the same P64k molecule, in order to enhance the immunogenicity of protein fragments.
topic dengue
vaccine
p64k
carrier
url http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1027-28522009000400006&lng=en&tlng=en
work_keys_str_mv AT lauralazo comparativeimmunogenicityandprotectivecapacityoftwodengue4vaccinecandidatesbasedonp64kenvelopedomainiii
AT lazarogil comparativeimmunogenicityandprotectivecapacityoftwodengue4vaccinecandidatesbasedonp64kenvelopedomainiii
AT aidazulueta comparativeimmunogenicityandprotectivecapacityoftwodengue4vaccinecandidatesbasedonp64kenvelopedomainiii
AT irisvaldes comparativeimmunogenicityandprotectivecapacityoftwodengue4vaccinecandidatesbasedonp64kenvelopedomainiii
AT yordankasoria comparativeimmunogenicityandprotectivecapacityoftwodengue4vaccinecandidatesbasedonp64kenvelopedomainiii
AT yaremisromero comparativeimmunogenicityandprotectivecapacityoftwodengue4vaccinecandidatesbasedonp64kenvelopedomainiii
AT gerardoguillen comparativeimmunogenicityandprotectivecapacityoftwodengue4vaccinecandidatesbasedonp64kenvelopedomainiii
AT lissethermida comparativeimmunogenicityandprotectivecapacityoftwodengue4vaccinecandidatesbasedonp64kenvelopedomainiii
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