Synergistic antitumor effect between gefitinib and fractionated irradiation in anaplastic oligodendrogliomas cannot be predicted by the Egfr signaling activity.

Synergistic antitumor effect between gefitinib and fractionated irradiation in anaplastic oligodendrogliomas cannot be predicted by the Egfr signaling activity.

In high-grade gliomas, the identification of patients that could benefit from EGFR inhibitors remains a challenge, hindering the use of these agents. Using xenografts models, we evaluated the antitumor effect of the combined treatment "gefitinib + radiotherapy" and aimed to identify the pr...

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Bibliographic Details
Main Authors: Sophie Pinel, Jihane Mriouah, Marc Vandamme, Alicia Chateau, François Plénat, Eric Guérin, Luc Taillandier, Valérie Bernier-Chastagner, Jean-Louis Merlin, Pascal Chastagner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3715478?pdf=render

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http://europepmc.org/articles/PMC3715478?pdf=render

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