Oophorectomy Reduces Estradiol Levels and Long-Term Spontaneous Neurovascular Recovery in a Female Rat Model of Focal Ischemic Stroke

Oophorectomy Reduces Estradiol Levels and Long-Term Spontaneous Neurovascular Recovery in a Female Rat Model of Focal Ischemic Stroke

Although epidemiological evidence suggests significant sex and gender-based differences in stroke risk and recovery, females have been widely under-represented in preclinical stroke research. The neurovascular sequelae of brain ischemia in females, in particular, are largely uncertain. We set out to...

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Bibliographic Details
Main Authors: Paolo Bazzigaluppi, Conner Adams, Margaret M. Koletar, Adrienne Dorr, Aleksandra Pikula, Peter L. Carlen, Bojana Stefanovic
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
arterial spin labeling
estrogen
ischemia
ovariectomy
local field potential
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00338/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00338/full

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