Interleukin-4 Induces CpG Site-Specific Demethylation of the Pendrin Promoter in Primary Human Bronchial Epithelial Cells

Interleukin-4 Induces CpG Site-Specific Demethylation of the Pendrin Promoter in Primary Human Bronchial Epithelial Cells

Pendrin is upregulated in bronchial epithelial cells following IL-4 stimulation via binding of STAT6 to an N4 GAS motif. Basal CpG methylation of the pendrin promoter is cell-specific. We studied if a correlation exists between IL-4 sensitivity and the CpG methylation status of the pendrin promoter...

Full description

Bibliographic Details
Main Authors: Giada Scantamburlo, Simone Vanoni, Silvia Dossena, Selma M. Soyal, Emanuele Bernardinelli, Davide Antonio Civello, Wolfgang Patsch, Markus Paulmichl, Charity Nofziger
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
Asthma
COPD
Lung
SLC26A4
STAT6
Online Access:http://www.karger.com/Article/FullText/470720

Internet

http://www.karger.com/Article/FullText/470720

Similar Items